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Research

Current Clinical Trials


Asthma Clinical Trials (Spring 2011)


Asthma Clinical Trials
Protocol Name: Stimulation of the cervical sympathetic Ganglion for Treatment of Asthma.
Sponsor: Neurosurgery / OSU Asthma Center
PI: Jonathan Parsons, MD
Coordinator: David Cosmar
Synopsis: The purpose of this study is to evaluate if stimulating the nerve involved with airway constriction, while undergoing procedures that are known to cause asthma exacerbations, decreases the level of asthma attack experienced.
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Protocol Name: The Asthma Registry for Contact and Possible Participation in a Future Asthma Research Study
Sponsor: Pulmonary Division/ OSU Asthma Center
PI: John Mastronarde, MD / Jonathan Parsons, MD
Coordinator: David Cosmar
Synopsis: Asthma registry for patients diagnosed with asthma who may be eligible for future studies.
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Protocol Name: Micro RNA signatures in acute asthma exacerbations
Sponsor: Pulmonary Division/ OSU Asthma Center
PI: John Mastronarde, MD
Coordinator: David Cosmar
Synopsis: This is a non-randomized, cohort study of the patterns of microvesicles in the serum of participants with atopic and non-atopic asthma.
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Protocol Name: Exercise-induced Bronchospasm in Cystic Fibrosis
Sponsor: Pulmonary Division/ OSU Asthma Center
PI: John Mastronarde, MD; Stephen Kirkby, MD; Karen McCoy, MD
Coordinator: David Cosmar
Synopsis: This study is designed to determine how often exercise-induced bronchospasm occurs in patients with cystic fibrosis.
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Protocol Name: The Study of Soy Isoflavones in Asthma (SOYA)
Sponsor: ALA- ACRC / NIH
PI: John Mastronarde, MD
Coordinator: David Cosmar
Synopsis: This study is being done to see if soy has an effect on asthma severity.
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Protocol Name: The Study of Asthma and Nasal Steroids (STAN)
Sponsor: ALA- ACRC / NIH
PI: John Mastronarde, MD
Coordinator: David Cosmar
Synopsis: The objective of this clinical trial is to determine if treatment of chronic rhinitis and sinusitis improves control of asthma in children and adults.
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Protocol Name: Inflammatory Mediators and microRNA Analysis in Premenstrual Asthma
Sponsor: National Institute of Health (NIH)
PI: Jennifer McCallister, MD
Coordinator: David Cosmar
Synopsis: This study is being done to investigate the possible causes of this premenstrual increase in asthma symptoms and to help asthma care providers identify those patients who may suffer from this condition.
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Protocol Name: A Phase 2b, Dose-ranging Study to Evaluate the Efficacy and Safety of MEDI-563 in Adults with Uncontrolled Asthma
Sponsor: Medimmune
PI: Jon Parsons, MD
Coordinator: David Cosmar
Synopsis: The purpose of this study is to see if MEDI-563, given as an injection under the skin, can help reduce asthma attacks and improve your asthma symptoms.

Protocol Name: A Prospective Observational Study to Assess the Role of Selected Biomarkers in Subjects Requiring Daily Medium- to High-dose Inhaled Corticosteroids for Persistent Asthma
Sponsor: Medimmune
PI: Jon Parsons, MD
Coordinator: David Cosmar
Synopsis: The primary objective of this study is to find relationships between markers of inflammation and adults using medium-to-high dose inhaled corticosteroids.